Disturbances of protein metabolism – decreased muscle mass, increased creatine phosphokinase-, anemia, lipid metabolism – increased lipoprotein and cholesterol metabolism disorders mucopolysaccharides, which are major component of interstitial substance of tissue – accumulation in the tissues of hyaluronic acid and chondroitin sulfate. The increase in tissue content of hyaluronic acid, which in aqueous solution has a gel-like consistency, and creates conditions for the formation of mucous edema (myxedema) is the cause of symptoms observed in hypothyroidism. Mucosal edema produced in the skin, subcutaneous tissue, the vocal cords, in mucous membranes of the nose and ears, which causes hoarseness and hearing loss. The accumulation of mucopolysaccharides in the striated muscle leads to disruption of their contractile capacity: in the heart muscle – to decrease in cardiac output, in the language – to slow and vague language, the musculature of the gastrointestinal tract – to slow peristalsis and intestinal atony. To produce hypothyroidism idiopathic atrophy of the thyroid gland, which usually occurs in postmenopausal women, autoimmune thyroiditis (Hashimoto's struma), accompanied by the gradual destruction of the gland tissue, reduction of weight due to thyroid tissue surgery, radiation therapy of the neck, the treatment of antithyroid drugs (merkazolil, tiamazol) and radioactive iodine treatment of hyperthyroidism on the use of iodine-containing medicines drugs. You should also remember that short-term slight decrease in thyroid hormones, including free fractions, with normal or slightly elevated TSH may occur In heavy infections, burns, starvation, surgery, myocardial infarction, renal and liver failure and other pathological conditions. In this case demonstrates the dynamic monitoring levels of thyroid hormones, which should return to normal with the improvement of the patient.